{"product_id":"alembic-docmycin-doxycycline-for-injection-usp-200mg-sterile-lyophilized-iv-infusion-tetracycline-antibiotic-veterinary-rx","title":"Alembic Docmycin Doxycycline for Injection USP 200mg | Sterile Lyophilized IV Infusion | Tetracycline Antibiotic | Veterinary Rx","description":"\u003cp\u003e\u003cstrong\u003ePRESCRIPTION VETERINARY MEDICINE — For veterinary use only. Must be prescribed and administered by or under the direct supervision of a licensed veterinarian. FOR INTRAVENOUS (IV) INFUSION ONLY — Do not administer by direct IV push or intramuscular injection. Must be reconstituted and diluted before administration. Administer by slow IV infusion only — rapid IV administration causes severe cardiovascular toxicity (hypotension, arrhythmia). Rx only. Keep out of reach of children. Store below 25°C. Protect from light.\u003c\/strong\u003e\u003c\/p\u003e\u003ch3\u003e\u003cstrong\u003eAlembic Docmycin® Doxycycline for Injection USP 200mg (Veterinary) | Sterile Lyophilized Powder for IV Infusion | Tetracycline Antibiotic | Veterinary Rx\u003c\/strong\u003e\u003c\/h3\u003e\u003cp\u003eAlembic Docmycin 200mg Injection is a sterile, lyophilized (freeze-dried) powder for reconstitution and intravenous infusion, containing Doxycycline Hyclate USP 200mg per vial — the higher-strength veterinary IV formulation for larger breed dogs and cats, or for cases requiring accelerated therapeutic loading. This parenteral formulation of Doxycycline is indicated for serious and systemic bacterial infections in dogs and cats where oral Doxycycline therapy is not feasible due to vomiting, severe illness, hospitalisation, or the clinical requirement for immediate therapeutic plasma concentrations. The 200mg vial provides greater dosing flexibility for larger patients and reduces reconstitution steps in high-dose protocols. Administer strictly as prescribed and supervised by a licensed veterinarian. Labelled for veterinary use (Veterinary marking on box).\u003c\/p\u003e\u003ch4\u003e\u003cstrong\u003eActive Ingredient \u0026amp; Formulation\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003eDoxycycline Hyclate USP 200mg — Sterile lyophilized powder:\u003c\/strong\u003e Each vial contains 200mg Doxycycline Hyclate (as Doxycycline Hyclate — the hydrochloride hemiethanol hemisolvate salt form selected for parenteral formulation due to superior aqueous solubility); the lyophilized powder is reconstituted with Sterile Water for Injection or 0.9% Sodium Chloride Injection, then further diluted in a compatible IV fluid (0.9% NaCl, 5% Dextrose in Water — D5W, or Lactated Ringer’s solution) to the appropriate infusion concentration before slow IV administration; the 200mg vial provides twice the active drug per vial compared to the 100mg formulation, suitable for medium and large breed dogs at standard Doxycycline dosing (5–10 mg\/kg twice daily) and for cats at weight-appropriate doses confirmed by veterinarian; reconstitution and administration protocol must be confirmed with the treating veterinarian and followed precisely; do not administer as rapid IV bolus — high peak plasma concentrations from rapid infusion cause direct myocardial depression and vasodilation resulting in acute cardiovascular toxicity (hypotension, bradycardia, arrhythmia)\u003c\/li\u003e\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\u003cli\u003e\n\u003cstrong\u003e30S ribosomal subunit inhibitor — bacteriostatic tetracycline (IV route):\u003c\/strong\u003e Doxycycline inhibits bacterial protein synthesis by reversibly binding the 30S ribosomal subunit 16S rRNA h34 helix (A-site), blocking aminoacyl-tRNA accommodation and halting peptide chain elongation; IV administration delivers 100% bioavailability with immediate therapeutic serum concentrations, bypassing oral bioavailability variability; high tissue distribution and intracellular penetration — Doxycycline accumulates within macrophages and neutrophils, delivering antibiotic directly to the intracellular compartment where obligate intracellular pathogens (Ehrlichia, Anaplasma, Rickettsia) reside within membrane-bound vacuolar inclusions (morulae); for complete mechanism detail see Alembic Docmycin Tablets and Docmycin 100mg Injection listings\u003c\/li\u003e\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eSevere or systemic tick-borne infections in dogs and cats — Ehrlichia canis (tick fever\/canine monocytic ehrlichiosis), Anaplasma phagocytophilum (canine granulocytic anaplasmosis), Rickettsia spp. — in hospitalised patients unable to tolerate oral medication\u003c\/li\u003e\n\u003cli\u003eSevere leptospirosis (Leptospira interrogans) — parenteral Doxycycline for hospitalised patients with severe leptospiraemia, hepatic or renal involvement\u003c\/li\u003e\n\u003cli\u003eSerious bacterial infections in hospitalised dogs and cats (respiratory, urinary, skin and soft tissue) requiring parenteral antibiotic therapy\u003c\/li\u003e\n\u003cli\u003ePost-operative infection prophylaxis and treatment in hospitalised surgical patients\u003c\/li\u003e\n\u003cli\u003eIV-to-oral step-down: once the patient tolerates oral medication, transition to Alembic Docmycin oral tablets at the equivalent dose to complete the treatment course\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eReconstitution \u0026amp; Administration Protocol\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eReconstitute with specified volume of Sterile Water for Injection or 0.9% NaCl as per veterinarian’s protocol — see package insert for reconstitution details\u003c\/li\u003e\n\u003cli\u003eFurther dilute in compatible IV fluid (0.9% NaCl, D5W, or Lactated Ringer’s) to appropriate infusion concentration\u003c\/li\u003e\n\u003cli\u003eAdminister by slow IV infusion over minimum 1–2 hours — never by rapid IV bolus or direct IV push\u003c\/li\u003e\n\u003cli\u003eUse aseptic technique throughout preparation and administration; prepare immediately before use; discard unused reconstituted solution\u003c\/li\u003e\n\u003cli\u003eMonitor patient during infusion for phlebitis at infusion site and cardiovascular adverse reactions\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eContraindications \u0026amp; Safety\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eIV infusion only — never by rapid bolus, IM, or SC injection\u003c\/li\u003e\n\u003cli\u003eDo not use in puppies under 6 months or pregnant\/lactating females — Doxycycline chelates calcium in developing bone and dental matrix causing permanent discolouration (yellow-brown fluorescence under UV) and enamel hypoplasia; retards linear bone growth in growth plate cartilage\u003c\/li\u003e\n\u003cli\u003eDo not mix with calcium-containing IV fluids at high concentrations — calcium-Doxycycline chelation precipitates drug from solution; Lactated Ringer’s is generally compatible at low concentrations, confirm compatibility before use\u003c\/li\u003e\n\u003cli\u003ePhlebitis risk: Doxycycline is a venous irritant at high concentrations; ensure adequate dilution and slow infusion rate; monitor IV catheter site\u003c\/li\u003e\n\u003cli\u003eUse with caution in dogs and cats with hepatic impairment — biliary\/faecal excretion is the primary route; hepatic disease may elevate plasma concentrations\u003c\/li\u003e\n\u003cli\u003eStore below 25°C; protect from light; keep in original packaging; do not use beyond expiry date on vial label\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Paws \u0026 Tails™","offers":[{"title":"Default Title","offer_id":47462685737135,"sku":"DOCMYCIN-INJ-200MG","price":360.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0316\/4079\/files\/ChatGPT_Image_Sep_8_2026_07_40_09_PM.png?v=1788876757","url":"https:\/\/sg37v1-ta.myshopify.com\/products\/alembic-docmycin-doxycycline-for-injection-usp-200mg-sterile-lyophilized-iv-infusion-tetracycline-antibiotic-veterinary-rx","provider":"Paws \u0026 Tails™","version":"1.0","type":"link"}