{"product_id":"bioiberica-probioplus-probiotic-sachets-for-dogs-30-sachets","title":"Bioibérica ProbioPlus Probiotic Sachets for Dogs | Enterococcus faecium + FOS + MOS + Beta-Glucans + Vitamins | Gut Microbiota Immune Support Stool Consistency | 30 Sachets x 2.5g","description":"\u003cp\u003e\u003cstrong\u003eVETERINARY USE ONLY. For use in dogs. Administer as directed by a veterinarian. Store in a cool, dry place away from direct sunlight. Once opened, consume immediately. Keep out of reach of children.\u003c\/strong\u003e\u003c\/p\u003e\u003ch3\u003e\u003cstrong\u003eBioibérica ProbioPlus Probiotic Sachets for Dogs (30 Sachets × 2.5g)\u003c\/strong\u003e\u003c\/h3\u003e\u003cp\u003eBioibérica ProbioPlus is a veterinary probiotic and prebiotic complementary feed for dogs, developed by Bioibérica — a leading Spanish animal health company. Each 2.5g sachet delivers a precisely formulated synbiotic combination of Enterococcus faecium (live probiotic strain), FOS (fructooligosaccharides), MOS (mannanoligosaccharides), beta-glucans, and vitamins. ProbioPlus is indicated to restore intestinal microbiota, support a strong immune system, and improve stool consistency in dogs. Suitable for dogs of all breeds, sizes, and ages including puppies, adults, and senior dogs. 30 sachets per box.\u003c\/p\u003e\u003ch4\u003e\u003cstrong\u003eComposition (per 2.5g sachet)\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnterococcus faecium:\u003c\/strong\u003e Gram-positive lactic acid bacterium; live probiotic strain; primary probiotic active in ProbioPlus (confirm CFU count from label)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFOS — Fructooligosaccharides:\u003c\/strong\u003e Soluble prebiotic dietary fibre; selectively fermented by Bifidobacterium and Lactobacillus species\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMOS — Mannanoligosaccharides:\u003c\/strong\u003e Prebiotic derived from Saccharomyces cerevisiae yeast cell wall mannoprotein\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBeta-glucanos — Beta-glucans:\u003c\/strong\u003e β-1,3\/1,6-glucan immunomodulatory polysaccharide derived from yeast or cereal\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVitaminas — Vitamins:\u003c\/strong\u003e Confirm specific vitamin blend (likely Vitamins A, C, D, E, B-complex) from label\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eExcipientes c.s.p. — Excipients q.s.:\u003c\/strong\u003e Sachet base\/carrier; confirm from label\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eMechanisms of Action\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eEnterococcus faecium — Probiotic Mechanisms:\u003c\/strong\u003e E. faecium is one of the most extensively studied and validated veterinary probiotic strains (SF68 strain widely used in companion animals); mechanisms: (1) competitive exclusion — E. faecium colonises intestinal epithelial adhesion sites, competitively excluding enteric pathogens (E. coli, Salmonella, Clostridium perfringens, Campylobacter) from binding and colonising the mucosa; (2) lactic acid and bacteriocin production — E. faecium produces L-lactic acid (reducing luminal pH, inhibiting acid-sensitive pathogens) and bacteriocins (enterocins — antimicrobial peptides targeting Gram-positive pathogens including Listeria, Staphylococcus, and Clostridium); (3) tight junction reinforcement — E. faecium upregulates expression of tight junction proteins (occludin, claudin-1, ZO-1) at intestinal epithelial cell junctions, reducing intestinal permeability (‘leaky gut’) and preventing bacterial translocation; (4) immune modulation — E. faecium interacts with intestinal dendritic cells and Peyer’s patch macrophages via TLR-2 and NOD2 pattern recognition receptors, promoting tolerogenic immune responses (Treg\/IL-10\/IL-12 balance) and mucosal IgA secretion; (5) restoration of post-antibiotic dysbiosis — E. faecium is naturally resistant to several antibiotics and survives antibiotic treatment courses, providing a seeding population for microbiome restoration during and after antibiotic therapy\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFOS — Fructooligosaccharides (Prebiotic):\u003c\/strong\u003e FOS are short-chain β-fructose polymers (degree of polymerisation 2–8); selectively fermented by Bifidobacterium longum, B. animalis, Lactobacillus acidophilus, and E. faecium in the large intestine; fermentation produces short-chain fatty acids (SCFA) — principally butyrate, propionate, and acetate; butyrate is the primary energy substrate for colonocytes (large intestinal epithelial cells), supporting colonocyte proliferation, mucosal barrier repair, and anti-inflammatory effects via inhibition of NF-κB and HDAC (histone deacetylase) in colonocytes; FOS increase Bifidobacterium and Lactobacillus relative abundance while reducing Clostridium, Enterobacteriaceae, and Bacteroides populations; FOS also increase faecal water content and stool bulk, improving stool consistency in both constipated and diarrhoeic dogs\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMOS — Mannanoligosaccharides (Prebiotic \u0026amp; Pathogen Blocker):\u003c\/strong\u003e MOS is derived from the outer mannoprotein layer of Saccharomyces cerevisiae yeast cell walls; dual mechanism: (1) pathogen adhesion blocking — type 1 fimbriated enteric pathogens (Salmonella, E. coli) use mannose-binding lectins (FimH adhesin) on their fimbriae to adhere to mannose residues on intestinal epithelial cells; MOS competitively binds to FimH lectins on pathogen fimbriae, blocking their adhesion to the intestinal epithelium and promoting their agglutination and faecal excretion; (2) immune stimulation — MOS binds to macrophage and dendritic cell mannose receptors (CD206, MRC1), activating innate immune responses including phagocytosis and pro-inflammatory cytokine production; MOS also binds and neutralises mycotoxins (aflatoxin B1, zearalenone, ochratoxin A) within the GI lumen\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBeta-glucans (β-1,3\/1,6-glucan) — Immunomodulator:\u003c\/strong\u003e Beta-glucans are polysaccharides from the yeast cell wall (β-1,3\/1,6-glucan) or cereal grains (oat\/barley β-1,3\/1,4-glucan); mechanism: beta-glucans bind Dectin-1 (CLEC7A, a C-type lectin receptor on macrophages, neutrophils, and dendritic cells) and complement receptor 3 (CR3\/Mac-1, CD11b\/CD18) on innate immune cells; Dectin-1 signalling activates the CARD9\/Bcl-10\/MALT1 complex, leading to NF-κB-mediated upregulation of pro-inflammatory cytokines (IL-1β, IL-6, IL-12, TNF-α) and reactive oxygen species (ROS) production; this ‘primes’ innate immune cells for enhanced pathogen killing; beta-glucans also activate the alternative complement pathway; net effect: enhanced phagocytosis of bacteria, fungi, and parasites; augmented NK cell cytotoxicity; potentiated vaccine immune responses; reduced infection susceptibility\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eKey Benefits (as stated on label)\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eContributes to restore intestinal microbiota (flora intestinal)\u003c\/li\u003e\n\u003cli\u003eFavours a strong immune system\u003c\/li\u003e\n\u003cli\u003eImproves stool consistency\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eTherapeutic Class\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\u003cli\u003eVeterinary synbiotic (probiotic + prebiotic) complementary feed — Enterococcus faecium + FOS + MOS + beta-glucans + vitamins — gut microbiota restoration, immune support, stool consistency — dogs all breeds and ages — Bioibérica (Spain)\u003c\/li\u003e\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eRestoration of gut microbiota after antibiotic therapy or GI illness\u003c\/li\u003e\n\u003cli\u003eChronic or recurrent diarrhoea and loose stools in dogs\u003c\/li\u003e\n\u003cli\u003ePost-infectious GI recovery (parvovirus, bacterial enteritis, parasitic infection)\u003c\/li\u003e\n\u003cli\u003eGut dysbiosis and microbiome imbalance\u003c\/li\u003e\n\u003cli\u003eImmune system support and modulation\u003c\/li\u003e\n\u003cli\u003eDaily gut health maintenance in dogs of all breeds and ages\u003c\/li\u003e\n\u003cli\u003eStress-associated GI upset (boarding, travel, dietary change)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eMix contents of one sachet (2.5g) with food\u003c\/li\u003e\n\u003cli\u003eConfirm daily dose and duration from product label or as directed by a veterinarian\u003c\/li\u003e\n\u003cli\u003e30 sachets per box; once opened consume sachet immediately\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eSafety Information\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eVeterinary use only; for use in dogs\u003c\/li\u003e\n\u003cli\u003eGenerally very well tolerated; mild transient flatulence may occur during first few days of use as gut microbiome adjusts\u003c\/li\u003e\n\u003cli\u003eStore in a cool, dry place away from direct sunlight; once opened consume immediately\u003c\/li\u003e\n\u003cli\u003eKeep out of reach of children\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Paws \u0026 Tails™","offers":[{"title":"Default Title","offer_id":47456004473007,"sku":null,"price":2499.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0316\/4079\/files\/ChatGPTImageSep7_2026_08_20_31PM.png?v=1788792945","url":"https:\/\/sg37v1-ta.myshopify.com\/products\/bioiberica-probioplus-probiotic-sachets-for-dogs-30-sachets","provider":"Paws \u0026 Tails™","version":"1.0","type":"link"}