{"product_id":"vivaldis-vetecto-spot-on-fluralaner-for-dogs-tick-flea-treatment","title":"Vivaldis Vetecto Spot On 1000 MG 3.6 ML for 20-40 KG Dogs | Fluralaner Isoxazoline | Tick \u0026 Flea Treatment | Topical Spot-On","description":"\u003cp\u003e\u003cstrong\u003eVETERINARY PRESCRIPTION RECOMMENDED. FOR EXTERNAL USE IN DOGS ONLY. Apply as directed by a veterinarian. Do not use in cats. Keep out of reach of children. Keep treated dogs away from water for 48 hours post-application. Store away from heat and direct sunlight.\u003c\/strong\u003e\u003c\/p\u003e\u003ch3\u003e\u003cstrong\u003eVivaldis Vetecto Spot On for Dogs | Fluralaner Isoxazoline Topical Ectoparasiticide\u003c\/strong\u003e\u003c\/h3\u003e\u003cp\u003eVivaldis Vetecto Spot On is a topical ectoparasiticide for dogs containing Fluralaner — an isoxazoline-class systemic insecticide and acaricide. Unlike conventional topical spot-ons that kill ectoparasites on contact with the skin surface, Fluralaner is absorbed dermally and distributes systemically via the bloodstream, killing ticks and fleas when they bite the treated dog. A single monthly spot-on application provides sustained protection against tick and flea infestations for up to 30 days. The spot-on format provides a no-mess, no-chew alternative to oral isoxazoline tablets for dogs where oral administration is challenging.\u003c\/p\u003e\u003ch4\u003e\u003cstrong\u003eComposition\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\u003cstrong\u003eFluralaner: as per label concentration (%w\/v)\u003c\/strong\u003e\u003c\/li\u003e\n\u003cli\u003eExcipients: topical solution base (as per label)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eDrug Class\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\u003cli\u003eVeterinary topical ectoparasiticide — Isoxazoline class — Fluralaner — systemic insecticide and acaricide — tick and flea treatment and prevention — dogs\u003c\/li\u003e\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eMechanism of Action\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGABA-gated and glutamate-gated chloride channel antagonism (invertebrate-selective):\u003c\/strong\u003e Fluralaner is an isoxazoline compound that potently antagonises GABA (gamma-aminobutyric acid)-gated chloride channels (GABA−Cl− channels) and glutamate-gated chloride channels (GluCl channels) in invertebrate nervous systems; in insects (fleas) and arachnids (ticks), GABAergic interneurons and motor neurons are tonically regulated by GABA-gated Cl− influx (membrane hyperpolarisation — inhibitory neurotransmission); Fluralaner blocks GABA-gated Cl− influx at insect\/arachnid GABA receptor subtypes — specifically binding at the picrotoxin site within the chloride channel pore (RDL-type subunit in insects); channel blockade prevents Cl− influx → sustained membrane depolarisation of invertebrate motor neurons → uncontrolled neuronal excitation → tonic muscle spasms, uncoordinated movement, paralysis, and death of the ectoparasite; Fluralaner concurrently antagonises invertebrate GluCl channels (expressed in invertebrate neuromuscular junctions — absent in vertebrates), compounding ectoparasiticide activity; selectivity for invertebrate vs. mammalian GABA-A receptors (mammalian GABA-A receptors have distinct subunit composition — primarily α1β2γ heteromers with benzodiazepine-sensitive γ-subunits and low isoxazoline binding affinity) provides the safety margin in dogs; CNS penetration in dogs is additionally limited by P-glycoprotein (MDR1\/ABCB1) blood-brain barrier efflux — MDR1-deficient breeds (Collies, Australian Shepherds, Shelties, Border Collies, Whippets) may have reduced CNS Fluralaner efflux; at therapeutic spot-on doses this is generally well-tolerated but veterinary guidance is recommended for MDR1-deficient breeds\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSystemic distribution following dermal absorption:\u003c\/strong\u003e Following spot-on application at the base of the skull\/back of neck, Fluralaner is absorbed transdermally into the dermal vasculature and distributed systemically via plasma; Fluralaner is highly lipophilic and extensively plasma protein-bound; it achieves plasma concentrations sufficient to kill Ixodes, Rhipicephalus, Haemaphysalis, and Amblyomma ticks within 12–48 hours of attachment and Ctenocephalides fleas within 8–12 hours; the long plasma half-life of Fluralaner in dogs (≈15 days) maintains ectoparasiticidal plasma concentrations above the killing threshold for the full 30-day inter-application interval from a single spot-on application; unlike surface-contact topicals (e.g. Fipronil), systemic distribution means ectoparasite kill does not depend on the ectoparasite physically contacting the treated skin surface — it requires the ectoparasite to feed on the dog’s blood\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpectrum of activity — ticks:\u003c\/strong\u003e Ixodes ricinus and Ixodes scapularis (Lyme disease, Anaplasmosis, Babesiosis vectors), Rhipicephalus sanguineus (Ehrlichiosis, Babesia canis vectors — primary tick species in India), Amblyomma americanum (Ehrlichiosis, RMSF vector), Haemaphysalis spp. (Kyasanur Forest Disease vector — India-relevant); adult and nymphal ticks killed within 12–48 hours of attachment (typically before sufficient feeding time for pathogen transmission for most tick-borne diseases)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSpectrum of activity — fleas:\u003c\/strong\u003e Ctenocephalides felis (cat flea — primary flea species infesting dogs in India) and Ctenocephalides canis (dog flea); adult fleas killed within 8–12 hours of attachment and feeding\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eIndications\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eTreatment and prevention of tick infestations (Ixodes, Rhipicephalus, Amblyomma, Haemaphysalis spp.) in dogs\u003c\/li\u003e\n\u003cli\u003eTreatment and prevention of flea infestations (Ctenocephalides felis, C. canis) in dogs\u003c\/li\u003e\n\u003cli\u003ePrevention of tick-borne diseases (Ehrlichiosis, Babesiosis, Lyme disease, Anaplasmosis) by rapid tick kill before pathogen transmission\u003c\/li\u003e\n\u003cli\u003eMonthly ectoparasite prevention in dogs in tick and flea-endemic regions (including India)\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Application\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eTopical spot-on: apply entire contents of the weight-appropriate pipette directly to skin at the base of the skull \/ back of neck\u003c\/li\u003e\n\u003cli\u003ePart the fur to ensure direct skin contact; do not apply to broken, inflamed, or irritated skin\u003c\/li\u003e\n\u003cli\u003eApply once monthly; do not bathe or allow swimming for 48 hours post-application to maximise dermal absorption\u003c\/li\u003e\n\u003cli\u003eConfirm weight-appropriate pipette size with a veterinarian before first use\u003c\/li\u003e\n\u003c\/ul\u003e\u003ch4\u003e\u003cstrong\u003eContraindications \u0026amp; Safety\u003c\/strong\u003e\u003c\/h4\u003e\u003cul\u003e\n\u003cli\u003eDo not use in cats — formulated for dogs only\u003c\/li\u003e\n\u003cli\u003eDo not use in puppies under 8 weeks of age or under 2kg body weight (confirm label minimum age\/weight)\u003c\/li\u003e\n\u003cli\u003eUse with caution in dogs with a history of seizures or neurological disorders\u003c\/li\u003e\n\u003cli\u003eUse with veterinary caution in MDR1\/ABCB1-deficient breeds (Collies, Australian Shepherds, Shelties, Border Collies, Whippets)\u003c\/li\u003e\n\u003cli\u003eAvoid contact with eyes and mucous membranes during application\u003c\/li\u003e\n\u003cli\u003eKeep treated dogs away from water bodies — Fluralaner (isoxazoline) has ecotoxicological activity in aquatic invertebrates; do not allow treated dogs to swim in natural water bodies for 48 hours post-application\u003c\/li\u003e\n\u003cli\u003eMost common adverse effects: mild transient skin reactions at the application site; occasional GI signs (vomiting, diarrhoea) if product is accidentally ingested by licking\u003c\/li\u003e\n\u003cli\u003eStore in a cool, dry place away from heat, flame, and direct sunlight\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Paws \u0026 Tails™","offers":[{"title":"1 Pc","offer_id":47458133082287,"sku":null,"price":847.0,"currency_code":"INR","in_stock":true},{"title":"2 Pcs","offer_id":47458133115055,"sku":null,"price":1699.0,"currency_code":"INR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0729\/0316\/4079\/files\/ChatGPTImageSep8_2026_09_53_03AM.png?v=1788841400","url":"https:\/\/sg37v1-ta.myshopify.com\/products\/vivaldis-vetecto-spot-on-fluralaner-for-dogs-tick-flea-treatment","provider":"Paws \u0026 Tails™","version":"1.0","type":"link"}