Oriheal Palactin Ivermectin Antiparasitic Tablets for Dogs | 3mg & 10mg

PRESCRIPTION VETERINARY MEDICINE — For veterinary use only. Must be prescribed and dispensed by or under the supervision of a licensed veterinarian. IVERMECTIN IS CONTRAINDICATED IN COLLIES, SHELTIES, AUSTRALIAN SHEPHERDS, AND RELATED MDR1/ABCB1 GENE MUTATION-POSITIVE BREEDS — can cause fatal neurotoxicity in these breeds. Do not use in dogs under 6 weeks of age. Do not use in heartworm-positive dogs without prior heartworm adulticidal treatment and veterinary assessment. Do not use in dogs with known hypersensitivity to Ivermectin. Keep out of reach of children. Store in a cool, dry place away from direct sunlight.

If your dog is a herding breed or a herding cross, do not give this until your veterinarian says so. Collies, Shelties, Australian Shepherds, Border Collies, Old English Sheepdogs and their crosses frequently carry the MDR1 gene mutation, which lets ivermectin cross into the brain instead of being pumped out. In these dogs a dose that is routine for another animal can cause tremors, blindness, coma and death. A genetic test is available and is worth doing before ivermectin is used in any dog of uncertain herding ancestry, which in India includes a great many indies and mixed breeds whose parentage nobody knows. The dose depends entirely on what is being treated. The amount used to prevent heartworm is a tiny fraction of the amount used for mange, and these tablet strengths are intended for the higher-dose indications — never give a mange dose as a monthly preventive, and confirm with your veterinarian which indication your prescription is for. For dogs only. Do not give to cats, or to any other species, without specific veterinary direction. Ivermectin toxicity is an emergency: dilated pupils, wobbliness, tremors, drooling, disorientation, apparent blindness, collapse or seizures mean go to a veterinarian at once and take the packet with you.

Oriheal Palactin Ivermectin Tablets for Dogs (3mg & 10mg)

Oriheal Palactin is a prescription veterinary broad-spectrum antiparasitic tablet for dogs, containing Ivermectin — a macrocyclic lactone derived from Streptomyces avermitilis. Ivermectin is one of the most widely used veterinary antiparasitic agents, with broad activity against both ectoparasites (mites, lice) and endoparasites (GI nematodes, microfilariae). It remains a mainstay for demodectic and sarcoptic mange, where months of daily treatment may be needed and few alternatives are as cost-effective. Available in 3mg and 10mg tablet strengths. Administer strictly as directed by a licensed veterinarian.

Active Ingredient

• Ivermectin — 3mg or 10mg per tablet (confirm from Oriheal Palactin product label): Macrocyclic lactone antiparasitic agent; derived from Streptomyces avermitilis fermentation; mechanism of action — selectively binds to and potentiates glutamate-gated chloride ion channels (GluCl channels) present in invertebrate nerve and muscle cells; GluCl channel potentiation causes increased chloride ion permeability across the cell membrane, resulting in hyperpolarisation of nerve and muscle cells in parasites; hyperpolarisation causes irreversible flaccid paralysis and death of susceptible parasites; Ivermectin also potentiates GABA-gated chloride channels in invertebrates; mammalian safety margin is attributable to: (1) GluCl channels are absent in vertebrates; (2) GABA-gated channels in mammals are protected by the blood-brain barrier; (3) P-glycoprotein (encoded by the MDR1/ABCB1 gene) actively pumps Ivermectin out of the CNS in healthy dogs — CRITICAL: dogs with MDR1/ABCB1 gene mutations have impaired P-glycoprotein function, allowing Ivermectin accumulation in the CNS and causing fatal neurotoxicity
• Tablet excipients — confirm from Oriheal Palactin product label

Therapeutic Class

• Prescription veterinary macrocyclic lactone broad-spectrum antiparasitic tablet for dogs — demodicosis, sarcoptic mange, heartworm prevention, myiasis, and gastrointestinal nematode treatment

Indications

• Demodicosis (Demodex canis) — treatment of generalised and localised demodectic mange; Demodex mites live in hair follicles and sebaceous glands; treatment often requires extended courses, and your veterinarian will usually confirm resolution with repeat skin scrapes rather than by appearance alone
• Sarcoptic mange (Sarcoptes scabiei var. canis) — treatment of canine scabies, a highly pruritic and contagious infestation
• Heartworm prevention (Dirofilaria immitis) — prevention by eliminating larval stages before they develop into adult heartworms; preventive dosing differs completely from mange dosing; confirm the protocol with your veterinarian
• Myiasis (maggot wound infestation) — paralyses and kills fly larvae, supporting wound debridement alongside proper wound care
• Gastrointestinal nematodes — roundworm infestations (Toxocara canis, Toxascaris leonina, Ancylostoma caninum) and other Ivermectin-susceptible nematodes; confirm spectrum from the product label

Dosage

• Administer strictly as directed by a licensed veterinarian — this is a prescription veterinary medicine
• Dosage varies enormously by indication — heartworm prevention, demodicosis, sarcoptic mange, and myiasis all use different doses and intervals, and the preventive dose is a small fraction of the mange dose; confirm the indication-specific dose from the product label or veterinary prescription
• The 3mg tablet is typically used for small to medium breed dogs; the 10mg tablet for medium to large breed dogs — confirm weight-based dosing from the product label
• Weigh your dog accurately rather than estimating
• Administer orally; can be given with or without food
• Complete the course prescribed, particularly for demodicosis, which relapses if stopped early

Contraindications

• CONTRAINDICATED IN MDR1/ABCB1 MUTATION-POSITIVE BREEDS: Collie (Rough and Smooth), Shetland Sheepdog (Sheltie), Australian Shepherd, Border Collie, McNab Shepherd, Old English Sheepdog, Silken Windhound, and related herding breed crosses — MDR1/ABCB1 gene mutation causes P-glycoprotein deficiency, allowing Ivermectin accumulation in the CNS; signs of toxicity include mydriasis, tremors, ataxia, hypersalivation, seizures, coma, and death; MDR1 genetic testing is available and recommended before Ivermectin use in any herding breed or cross
• Not for use in cats or other species without specific veterinary direction
• Do not use in dogs under 6 weeks of age
• Do not use in heartworm-positive dogs without prior assessment and adulticidal treatment — rapid killing of microfilariae in a patent heartworm-positive dog can cause anaphylactoid reactions; confirm heartworm status before starting prevention
• Do not use in dogs with known hypersensitivity to Ivermectin or any tablet excipient
• Use with caution in debilitated, geriatric, or immunocompromised dogs — confirm suitability with your veterinarian

Drug Interactions

• P-glycoprotein inhibitors (ketoconazole, spinosad, ciclosporin): Can inhibit P-glycoprotein efflux of Ivermectin from the CNS, increasing neurotoxicity risk even in dogs without the MDR1 mutation; avoid concurrent use or use only under close veterinary supervision
• Other macrocyclic lactones (milbemycin, moxidectin, selamectin): Additive antiparasitic and potential additive CNS toxicity; avoid concurrent use — check whether your existing spot-on or heartworm preventive already contains one

Safety Information

• Prescription veterinary medicine — must be prescribed and dispensed by or under the supervision of a licensed veterinarian
• Signs of Ivermectin toxicity: mydriasis (dilated pupils), ataxia (incoordination), tremors, hypersalivation, vomiting, apparent blindness, seizures, coma — contact a veterinarian immediately; Ivermectin toxicity is a veterinary emergency
• There is no specific reversal agent in general use; treatment is intensive supportive care, with intravenous lipid emulsion therapy used in severe cases — this must be carried out by a veterinarian, and recovery can take days
• Heartworm prevention: test for existing heartworm infection before starting a prevention programme
• Zoonotic risk: Sarcoptes scabiei can transiently infest people — handle affected dogs with care and consult a physician if skin lesions develop
• Treat all in-contact dogs for sarcoptic mange, and wash bedding, as the mite spreads readily
• Not for human use — keep out of reach of children
• Store in a cool, dry place away from direct sunlight; keep in original packaging