VetPlus Calmex Diffuser Refill 40ml for Dogs & Cats | Rose, Lavender & Chamomile Essential Oil Refill | 30-Day Continuous Calming Coverage Up to 70m² | Replacement for Calmex Diffuser Starter Kit

FOR ANIMAL USE ONLY — Use as directed by a veterinarian or as per label instructions. The Calmex Diffuser Refill is a veterinary aromatherapy calming product — not a veterinary medicine. For animals with severe anxiety, aggression, or compulsive disorders, veterinary behavioural assessment and a full multimodal management plan are recommended. Ensure adequate room ventilation during diffuser use. Do not allow direct contact between the essential oil liquid and pet skin or mucous membranes. In homes with birds, use with caution — consult a veterinarian before using any diffuser product in homes with pet birds. Use only with the VetPlus Calmex Diffuser plug-in unit; replace the plug-in unit every 12 months as indicated on the unit label. Do not use on an extension cord, multi-socket adaptor, or multi-plug; plug directly into a wall socket. Use only in an upright position to avoid spilling. Keep out of reach of children and animals.

VetPlus Calmex Diffuser Refill 40ml for Dogs & Cats | Rose, Lavender & Chamomile Essential Oil Refill | 30-Day Continuous Calming Coverage Up to 70m² | Replacement for Calmex Diffuser Starter Kit

VetPlus Calmex Diffuser Refill 40ml is the replacement essential oil refill bottle for the VetPlus Calmex Plug-In Diffuser Starter Kit. Each 40ml refill provides approximately 30 days of continuous aromatherapy calming coverage in rooms up to 70m², delivering the same VetPlus-developed blend of three calming essential oils — Rosa damascena (Rose), Lavandula angustifolia (True Lavender), and Matricaria recutita (German Chamomile) — as a continuous aromatic vapour throughout the living space. The refill bottle is designed specifically for use with the Calmex Diffuser plug-in unit (sold separately as the Calmex Plug-In Diffuser Starter Kit, which includes the unit and a first 40ml refill); this product is the ongoing consumable refill for continuous use after the starter kit refill is depleted.

Product Specifications

• Contents: 40ml essential oil blend (Rosa damascena, Lavandula angustifolia, Matricaria recutita)
• Coverage: up to 70m² per refill
• Duration: approximately 30 days of continuous use per refill
• Compatible unit: VetPlus Calmex Plug-In Diffuser (replace the plug-in unit every 12 months)
• Suitable for: dogs and cats
• Format: refill bottle only — diffuser plug-in unit not included

Active Essential Oils & Calming Mechanisms

• Rosa damascena (Damask Rose) — citronellol, geraniol & phenylethanol: citronellol and geraniol positively modulate GABA-A receptors at the benzodiazepine binding pocket (α/γ subunit interface) → increased Cl− channel open-state probability → CNS inhibitory/anxiolytic effect; geraniol also acts as a 5-HT1A partial agonist (same target as buspirone — anxiolytic without sedation); 2-phenylethanol produces CNS depressant effects via GABA-A potentiation
• Lavandula angustifolia (True Lavender) — linalool & linalyl acetate — the best-evidenced aromatherapy calming oil in companion animals: linalool inhibits N-type (CaV2.2) and P/Q-type (CaV2.1) voltage-gated calcium channels (the same alpha-2-delta subunit mechanism as pregabalin/gabapentin — used clinically for noise phobia in dogs) → reduces presynaptic glutamate, substance P, and noradrenaline release; additionally antagonises NMDA receptors (reducing fear memory LTP reconsolidation in the amygdala) and positively modulates GABA-A; the anxiolytic effect is olfactory-specific — confirmed absent in anosmic animals — making continuous diffuser delivery the correct and effective route; veterinary evidence: Shepherd (JAVMA 2006), Wells (AABS 2006), and Graham et al. (Physiol Behav 2005) demonstrated significant reductions in kennelled dog stress behaviours and travel-induced excitement with lavender aromatherapy exposure
• Matricaria recutita (German Chamomile) — (−)-α-bisabolol, chamazulene & apigenin: (−)-α-bisabolol antagonises 5-HT2A receptors (reducing amygdalar activation; same mechanism as quetiapine) and positively modulates GABA-A; chamazulene inhibits 5-LOX (reducing neuroinflammatory leukotriene LTB4/CysLT1-mediated amygdala hyperactivation) and scavenges ROS via its azulene ring; apigenin (4′,5,7-trihydroxyflavone) is a partial agonist at the benzodiazepine site on GABA-A (Ki ∼4μM) → anxiolytic without sedation; the triple GABA-A PAM synergy of all three oils via three independent binding sites on the GABA-A receptor complex provides additive anxiolytic activity
• Olfactory-amygdala pathway: essential oil molecules detected by the canine (300 million ORNs, 811 functional OR genes, 170cm² epithelium) and feline (200 million ORNs, 750 OR genes) olfactory systems project directly to the amygdala via the olfactory bulb → piriform cortex → entorhinal cortex pathway — bypassing the thalamic relay required by all other sensory modalities — enabling rapid and potent limbic modulation by airborne essential oil molecules

Indications

• Ongoing continuous calming support for dogs and cats — replacement refill after the Calmex Diffuser Starter Kit 40ml refill is depleted
• Separation-related behaviours, noise phobias (fireworks, thunder), multi-pet household tension, new environment adjustment, boarding and veterinary visit preparation
• Long-term maintenance environmental calming as part of a multimodal behaviour management programme

Directions for Use

• Attach the 40ml refill bottle to the Calmex Plug-In Diffuser unit and turn into place; ensure the bottle is securely attached before plugging into a wall socket
• Plug the unit directly into a wall socket (do not use with extension cords, multi-socket adaptors, or multi-plug adaptors)
• Use only in an upright position to avoid spilling the contents
• Position the diffuser where the pet spends most time; keep away from bedding, litter trays, and food or water bowls
• Each 40ml refill provides approximately 30 days of continuous use covering up to 70m²
• Replace the plug-in unit every 12 months per VetPlus label instructions
• Ensure the room is ventilated — keep a door or window slightly ajar; do not use in a fully sealed room

Safety Information

• Not for consumption — for external diffuser use only
• Use only with VetPlus Calmex Diffuser plug-in units; not compatible with other brand diffuser units
• Do not use in homes with birds or avian pets without veterinary guidance
• Keep out of reach of children and animals; do not allow direct skin or mucous membrane contact with the liquid
• Store in a cool, dry place away from direct sunlight; essential oils degrade on UV exposure